Synthesis of 3,5-bis(fluoroalkyl)pyrazoles/pyrazolines <i>via</i> [3 + 2] cycloaddition of di/trifluoroacetohydrazonoyl bromides and trifluoromethyl-substituted alkenes
An efficient [3 + 2] cycloaddition reaction of difluoromethyl or trifluoromethyl hydrazonoyl bromides with trifluoromethyl-substituted alkenes was investigated to produce a variety of 3,5-bis(fluoroalkyl)pyrazoles/pyrazolines in moderate to good yields. This protocol features obvious advantages such as easily available and stable substrates, step economy, gram-scalability and simple operation, providing a novel and practical method for the preparation of 3,5-bis(fluoroalkyl)pyrazoles/pyrazolines.
Authors
- Yulai Hu (ORCID: https://orcid.org/0000-0002-9630-4150)
- Gaowang Yang (ORCID: https://orcid.org/0009-0005-5146-2082)
- Ying Fan (ORCID: https://orcid.org/0000-0001-5321-588X)
- Ke‐Hu Wang (ORCID: https://orcid.org/0000-0001-8246-3559)
- Danfeng Huang (ORCID: https://orcid.org/0000-0002-5848-1164)
- Peng Jin (ORCID: https://orcid.org/0000-0001-6925-9094)
- Junjiao Wang (ORCID: https://orcid.org/0000-0002-5091-5263)
- Ruikang K. Wang (ORCID: https://orcid.org/0000-0001-5169-8822)
- Zuyu Bai
Institutions
- Northwest Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1039/d4ob01160k
- Citations
- 3
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.62