Hydroxychloroquine-induced acute generalized exanthematous pustulosis with HLA-typing
Acute generalized exanthematous pustulosis (AGEP) is a rare drug reaction characterized by numerous pustules on an erythematous base. In some cases, hydroxychloroquine (HCQ) can cause AGEP. There is an association between HLA genes and AGEP according to pharmacogenomic studies. In this case report, we present the case of a 36-year-old female who developed HCQ-induced AGEP with HLA-typing. According to our findings, the patient had HLA-B 58:01, HLA-C 08:01, and HLA-A 02:06. A pharmacoeconomic perspective of HLA genotyping before drug prescription is shown in this result.
Authors
- Qiaoli Zheng (ORCID: https://orcid.org/0000-0001-8608-0707)
- Hao Cheng (ORCID: https://orcid.org/0000-0001-5089-6747)
- Na Jin (ORCID: https://orcid.org/0000-0001-9443-2784)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Pharmacogenomics
- Published
- 2024-10-12
- DOI
- https://doi.org/10.1080/14622416.2024.2430167
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.90
Funders
- National Natural Science Foundation of China
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province