Pharmacokinetics, toxicities, and tissue concentrations of belotecan sprayed by rotational intraperitoneal pressurized aerosol chemotherapy in a pig model
RIPAC using belotecan of 0.5 mg/m² and 1.5 mg/m² may be feasible with fewer hepatic and renal toxicities in pigs. Thus, belotecan of 1.5 mg/m² may be considered as the starting dose for RIPAC in a phase 1 trial.
Authors
- Yoo-Kyung Song
- Seung Jun Lee
- San Lee (ORCID: https://orcid.org/0000-0003-4834-8463)
- Seungmee Lee (ORCID: https://orcid.org/0000-0003-1405-2656)
- Hee Seung Kim (ORCID: https://orcid.org/0000-0001-6876-8671)
- Yoon Jeong Choi
- Se-Mi Kim
- S. Lee
Institutions
- Korea Telecom (South Korea) (KR)
- Seoul National University (KR)
- Yonsei University (KR)
- Seoul National University Hospital (KR)
- Chong Kun Dang Bio (South Korea) (KR)
- Wonju Severance Christian Hospital (KR)
- Dankook University Hospital (KR)
- Keimyung University (KR)
- Dankook University (KR)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3802/jgo.2025.36.e37
- Citations
- 1
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Stryker
- Seoul National University
- Seoul National University Hospital
- Ministry of Science and ICT, South Korea