Epidemiological insights into severe hepatitis in pediatric inpatients
There is limited statistical data on severe hepatitis among hospitalized children in China at a national level. This nationwide study analyzed data from 34,410 children hospitalized for severe hepatitis in mainland China from 2016 to 2022. The overall in-hospital mortality rate was 6.1%. Viral hepatitis accounted for 14.9% of cases, with hepatitis B being the most prevalent. Indeterminate etiology, present in 79.0% of cases, was an independent risk factor for mortality. Findings emphasize the need for enhanced diagnostic methods and targeted interventions for children with severe hepatitis of unknown cause and suggest focused hepatitis B monitoring in older children to improve outcomes. Establishing a dedicated surveillance system is crucial for improving the prognosis of children at high risk for in-hospital mortality due to severe hepatitis.
Authors
- Sifa Gao (ORCID: https://orcid.org/0009-0002-7728-338X)
- Yuelun Zhang (ORCID: https://orcid.org/0000-0001-7990-9003)
- Xudong Ma (ORCID: https://orcid.org/0000-0002-5943-0879)
- Dawei Liu (ORCID: https://orcid.org/0000-0003-1911-9207)
- Jieqin Chen
- Taisheng Li (ORCID: https://orcid.org/0000-0002-7050-5675)
- Qijun Shan (ORCID: https://orcid.org/0000-0001-8783-8057)
- Yujie Chen (ORCID: https://orcid.org/0009-0008-6267-4023)
- Fuping Guo
- Xiang Zhou (ORCID: https://orcid.org/0000-0001-8523-8082)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-3200-5506)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.isci.2024.111420
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology of the People's Republic of China
- Chinese Academy of Medical Sciences