Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young
Lean and healthy old men do not manifest AR as evidenced by potent increases in MPS and mTORC1 signalling following EAA intake and exercise. Maintained anabolic sensitivity with age appears to be a function of a compensatory increase in basal levels of proteins involved in anabolic signalling. Therefore, our results suggest that age per se does not appear to cause AR in human skeletal muscle.
Authors
- Gerrit van Hall (ORCID: https://orcid.org/0000-0002-2519-8127)
- William Apró (ORCID: https://orcid.org/0000-0003-1942-2919)
- Andrew Philp (ORCID: https://orcid.org/0000-0003-3860-4136)
- Oscar Horwath (ORCID: https://orcid.org/0000-0002-3500-2896)
- Mats Johansson (ORCID: https://orcid.org/0000-0003-4577-0976)
- Marcus Moberg (ORCID: https://orcid.org/0000-0003-3747-0148)
- Nathan Hodson (ORCID: https://orcid.org/0000-0003-1330-4030)
- Olav Rooyackers (ORCID: https://orcid.org/0000-0002-3391-5448)
- Sebastian Edman (ORCID: https://orcid.org/0000-0003-2921-833X)
- Eva Andersson (ORCID: https://orcid.org/0000-0001-9040-2158)
Institutions
- University of Technology Sydney (AU)
- Manchester Metropolitan University (GB)
- University of Copenhagen (DK)
- University of Toronto (CA)
- Centenary Institute (AU)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Swedish School of Sport and Health Sciences (SE)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/jcsm.13613
- Citations
- 8
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 2.61
Funders
- Åke Wiberg Stiftelse
- European Commission