Glucose-1-phosphate thymidylyltransferase promotes the production of 3-<i>O</i>-α-mycarosylerythronolide B in <i>Streptomyces coelicolor</i>
The RbfA enzyme from Saccharopolyspora erythraea was expressed in S. coelicolor M1152 along with the MEB biosynthesis pathway, resulting in a large increase in MEB production (>100-fold).
Authors
- Matthew A. Gregory (ORCID: https://orcid.org/0000-0003-4890-8977)
- Tony R. Larson (ORCID: https://orcid.org/0000-0003-1337-3482)
- Hong Gao
- Margaret C. M. Smith (ORCID: https://orcid.org/0000-0002-4150-0496)
- Swen Langer (ORCID: https://orcid.org/0000-0002-9684-1167)
Institutions
- Isomerase Therapeutics (United Kingdom) (GB)
- University of York (GB)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1093/jambio/lxae291
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yorkshire Forward
- Biotechnology and Biological Sciences Research Council