Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS
This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer's disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.
Authors
- Claudia Schwarz (ORCID: https://orcid.org/0000-0003-3234-912X)
- Andrea Dell’Orco (ORCID: https://orcid.org/0000-0002-3964-8360)
- Jeanette Melin (ORCID: https://orcid.org/0000-0002-3700-3921)
- Ariane Fillmer (ORCID: https://orcid.org/0000-0003-3333-6603)
- Layla Tabea Riemann (ORCID: https://orcid.org/0000-0001-5411-7288)
- Sylvain Lehmann (ORCID: https://orcid.org/0000-0001-6117-562X)
- Semiha Aydın (ORCID: https://orcid.org/0000-0002-1499-2034)
- Bernd Ittermann (ORCID: https://orcid.org/0000-0002-4087-471X)
- Stefan Cano (ORCID: https://orcid.org/0000-0001-9390-273X)
- Agnes Flöel (ORCID: https://orcid.org/0000-0002-1475-5872)
- Leslie Pendrill (ORCID: https://orcid.org/0000-0003-4349-500X)
- Peter Körtvélyessy (ORCID: https://orcid.org/0000-0001-9990-2458)
- Patty Hoede (ORCID: https://orcid.org/0000-0003-3733-2845)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Laura Göschel (ORCID: https://orcid.org/0000-0001-6592-2493)
- Ulrike Grittner (ORCID: https://orcid.org/0000-0003-2595-0224)
Institutions
- Physikalisch-Technische Bundesanstalt (DE)
- Inserm (FR)
- Universität Hamburg (DE)
- Université de Montpellier (FR)
- Universitätsmedizin Greifswald (DE)
- RISE Research Institutes of Sweden (SE)
- German Center for Neurodegenerative Diseases (DE)
- Humboldt-Universität zu Berlin (DE)
- Zimmer Biomet (Germany) (DE)
- Amsterdam Neuroscience (NL)
- University Medical Center Hamburg-Eppendorf (DE)
- Amsterdam University Medical Centers (NL)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14318
- Citations
- 9
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.64
Funders
- National Multiple Sclerosis Society
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- EU Joint Programme – Neurodegenerative Disease Research
- Multiple Sclerosis Society
- European Commission
- Deutsche Forschungsgemeinschaft
- ZonMw
- Fondation pour la Recherche Médicale
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland
- Selfridges Group Foundation
- European Metrology Programme for Innovation and Research