Clinical Pharmacology of Ketoprofen

Ketoprofen is approved for use in the symptomatic treatment of rheumatoid arthritis, osteoarthritis, pain, ankylosing spondylitis, acute gouty arthritis, tendinitis, bursitis, headache, postoperative dental pain and swelling, and primary dysmenorrhoea.Ketoprofen is rapidly absorbed following oral administration, is bound to plasma protein to 99%, is rapidly eliminated with an elimination half-life of 0.9 to 3.3 hours, and the dose of ketoprofen is 25 to 50 mg thrice-daily or 4 times-daily.The efficacy and safely of ketoprofen, the treatment of patients with ketoprofen, and the trials conducted with ketoprofen have been reviewed.Ketoprofen is hydroxylated into 3-hydroxy-ketoprofen by CYP2C8 and by CYP2C9 and is conjugated with glucuronic acid by UGT2B7.The concentration of ketoprofen in human tissues has been reviewed, and following topical application, ketoprofen accumulates in semitendinosus muscle and in tendon more extensively than in plasma.The pharmacokinetics of ketoprofen have been reviewed and following oral administration the time to reach the peak concentration of ketoprofen is 1.941.25 hours.The interaction of ketoprofen with drugs has been reviewed and ketoprofen is a safe drug and limited information is available about the toxicity induced by ketoprofen.The aim of this study is to review the efficacy and safely of ketoprofen, the treatment of patients with ketoprofen, and the trials conducted with ketoprofen.In addition, the metabolism of ketoprofen, the concentration of ketoprofen in human tissues, the pharmacokinetics of ketoprofen, the interaction of ketoprofen with drugs, and the toxicity induced by ketoprofen have been reviewed.