Single‐Cell Membrane Potential Stimulation and Recording by an Electrolyte‐Gated Organic Field‐Effect Transistor
Abstract The reliable stimulation and recording of electrical activity in single cells by means of organic bio‐electronics will be an important milestone in developing new low‐cost and highly biocompatible medical devices. This paper demonstrates extracellular voltage stimulation and single‐cell membrane potential recording by means of a dual‐gate electrolyte‐gated organic field‐effect transistors (EGOFET) employing 2,8‐Difluoro‐5,11‐bis(triethylsilylethynyl)anthradithiophene blended with polystyrene as active material. To obtain a sufficiently small footprint to allow bidirectional communication at the single cell level, the EGOFET technology has been scaled down implementing a Corbino layout, paving the way to the development of novel bidirectional Electrocorticography (ECoG) devices with a high spatial resolution. A specific and thorough analysis of the working mechanisms of EGOFET‐based bio‐sensors is reported, highlighting the importance of the device design and using an appropriate batch of measurements for the recording of the electrical activity of cells.
Authors
- Sarah Tonello (ORCID: https://orcid.org/0000-0002-7325-7988)
- Stefano Casalini (ORCID: https://orcid.org/0000-0003-3609-1154)
- Morten Gram Pedersen (ORCID: https://orcid.org/0000-0002-2639-2394)
- Sara Ruiz‐Molina (ORCID: https://orcid.org/0000-0002-8792-4411)
- Marco Buonomo (ORCID: https://orcid.org/0000-0001-7339-1549)
- Andrea Cester (ORCID: https://orcid.org/0000-0001-6583-1735)
- Alessandra Galli (ORCID: https://orcid.org/0000-0003-2416-0220)
- Mario Bortolozzi (ORCID: https://orcid.org/0000-0001-7198-9838)
- Marta Mas‐Torrent (ORCID: https://orcid.org/0000-0002-1586-005X)
- Simona Pisu (ORCID: https://orcid.org/0000-0002-8216-9090)
- Nicolò Lago (ORCID: https://orcid.org/0000-0001-7309-6697)
- Giada Giorgi (ORCID: https://orcid.org/0000-0001-9498-4722)
- Saralea Marino
Institutions
- University of Padua (IT)
- Agostino Gemelli University Polyclinic (IT)
- Veneto Institute of Molecular Medicine (IT)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Institut de Ciència de Materials de Barcelona (ES)
- Institute for Experimental Endocrinology and Oncology (IT)
Publication Details
- Journal
- Advanced Electronic Materials
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/aelm.202400134
- Citations
- 1
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.27
Funders
- Dipartimenti di Eccellenza
- Generalitat de Catalunya
- Università degli Studi di Padova
- European Regional Development Fund
- Agencia Estatal de Investigación