Marmosets as model systems for the study of Alzheimer's disease and related dementias: Substantiation of physiological tau 3R and 4R isoform expression and phosphorylation
Our results confirm both 3R and 4R tau isoform expression and phosphorylation residues in the marmoset brain, and emphasize the significance of marmosets with natural expression of AD-related hallmarks as important translational models for AD. Highlights We report comprehensive characterization of tau isoform expression in marmoset brains across the lifespan. 3R and 4R tau isoforms are expressed in marmoset brains at both the transcript and protein levels across ages. These data emphasize the significance of marmosets with natural expression of primate-specific traits that are important for the study of Alzheimer's disease.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Caroline M Watson (ORCID: https://orcid.org/0000-0001-6574-0833)
- Yongshan Mou
- Thais Rafael Guimarães (ORCID: https://orcid.org/0000-0001-8324-0269)
- Seung‐Kwon Ha
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Sangho Choi (ORCID: https://orcid.org/0009-0006-9106-7818)
- Afonso C. Silva (ORCID: https://orcid.org/0000-0002-6105-7567)
- Sarah Shapley (ORCID: https://orcid.org/0000-0003-3002-8664)
- Stacey J. Sukoff Rizzo (ORCID: https://orcid.org/0000-0002-1460-8127)
- Hasi Huhe
- Duc Minh Duong (ORCID: https://orcid.org/0000-0001-5880-1888)
- Amantha Thathiah (ORCID: https://orcid.org/0000-0002-3132-4409)
- Fang Wu (ORCID: https://orcid.org/0000-0003-3189-6148)
- Lauren K Hayrynen Schaeffer
Institutions
- Emory University (US)
- University of Pittsburgh (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14366
- Citations
- 11
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.59
Funders
- National Institutes of Health
- Feinstein Institutes for Medical Research
- National Institute on Aging