Homocysteine, neurodegenerative biomarkers, and <i>APOE</i> ε4 in neurodegenerative diseases
Hcy may contribute to neurodegeneration depending on the presence of the APOE ε4 allele and specific disease processes. Trials on vitamin B12 supplementation may consider stratifying by APOE genotype. Highlights Homocysteine (Hcy) was associated with neurodegenerative biomarkers across disease groups. Relationships with Hcy were predominantly found in apolipoprotein E (APOE) ε4 non-carriers. In Alzheimer's disease, associations between Hcy and phosphorylated tau 217 were found in APOE ε4 non-carriers only. Significant interactions existed between Hcy and APOE ε4 status on cognition.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- David F. Tang‐Wai (ORCID: https://orcid.org/0000-0001-9747-9967)
- Wendy Lou (ORCID: https://orcid.org/0000-0001-5590-8719)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- Corinne E. Fischer (ORCID: https://orcid.org/0000-0002-1047-0167)
- Robert A. Hegele (ORCID: https://orcid.org/0000-0003-2861-5325)
- Jennifer S. Rabin (ORCID: https://orcid.org/0000-0003-4754-2221)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Angela K. Troyer (ORCID: https://orcid.org/0000-0001-5660-4127)
- RuoDing Wang (ORCID: https://orcid.org/0000-0003-3088-7442)
- David A. Grimes (ORCID: https://orcid.org/0000-0002-2115-1866)
- Sali M.K. Farhan (ORCID: https://orcid.org/0000-0001-5936-0957)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Joel Ramı́rez-Emiliano (ORCID: https://orcid.org/0000-0001-9813-9120)
- Tarek K. Rajji (ORCID: https://orcid.org/0000-0002-8324-2560)
- Gustavo Saposnik (ORCID: https://orcid.org/0000-0002-5950-9886)
- Walter Swardfager (ORCID: https://orcid.org/0000-0002-0030-8908)
- Julia Zebarth (ORCID: https://orcid.org/0000-0002-5214-4503)
- Lisa Y. Xiong (ORCID: https://orcid.org/0000-0002-6342-9336)
- Malcolm A. Binns (ORCID: https://orcid.org/0000-0001-9998-6612)
- Nathan Herrmann (ORCID: https://orcid.org/0000-0001-9277-6110)
- Angela Roberts (ORCID: https://orcid.org/0000-0002-9226-8009)
- J. B. Orange (ORCID: https://orcid.org/0000-0002-2632-3049)
- Mario Masellis (ORCID: https://orcid.org/0000-0002-6244-2096)
- Di Yu (ORCID: https://orcid.org/0000-0002-1176-399X)
- William Z. Lin (ORCID: https://orcid.org/0000-0002-3610-5213)
- Roger A. Dixon
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Richard H. Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Toronto Rehabilitation Institute (CA)
- Ottawa Hospital (CA)
- Sahlgrenska University Hospital (SE)
- Health Sciences Centre (CA)
- Baycrest Hospital (CA)
- Toronto Dementia Research Alliance (CA)
- Occupational Cancer Research Centre (CA)
- Public Health Ontario (CA)
- UK Dementia Research Institute (GB)
- Women and Children’s Health Research Institute (CA)
- Ontario Brain Institute (CA)
- Ottawa Hospital Research Institute (CA)
- Sunnybrook Research Institute
- University College London (GB)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14376
- Citations
- 8
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- University of Ottawa
- Ontario Brain Institute
- McMaster University
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Government of Ontario
- Centre for Addiction and Mental Health Foundation
- Bruyère Research Institute
- London Health Sciences Foundation
- National Institute for Health and Care Research
- University College London
- European Commission
- Fondation Leducq
- Canada Research Chairs
- Queen's University
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Temerty Family Foundation
- Ministry of Colleges and Universities
- HORIZON EUROPE Framework Programme
- Canadian Institutes of Health Research
- Faculty of Health Sciences, Queen's University