Caregiver perspectives enable accurate diagnosis of neurodegenerative disease
We analyzed 4952 questionnaires from caregivers of 2481 participants with neurodegenerative disease. Behavioral and neuropsychiatric manifestations of neurodegenerative disease had overlapping diagnostic boundaries. Simple questionnaire response patterns were sufficient for accurate diagnosis of each disease. We reinforce the value of a collateral history to support a diagnosis of dementia. The Cambridge Behavioural Inventory is sensitive to change over time and suitable as an outcome measure in clinical trials.
Authors
- Caroline H. Williams‐Gray (ORCID: https://orcid.org/0000-0002-2648-9743)
- Lucy Bowns
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Timothy Rittman (ORCID: https://orcid.org/0000-0003-1063-6937)
- Marta Camacho (ORCID: https://orcid.org/0000-0002-1490-5703)
- Alexander G. Murley (ORCID: https://orcid.org/0000-0003-0813-0670)
- Kamen A. Tsvetanov (ORCID: https://orcid.org/0000-0002-3178-6363)
- Roger A. Barker (ORCID: https://orcid.org/0000-0001-8843-7730)
Institutions
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14377
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Wellcome Trust
- Alzheimer's Society
- National Institute for Health and Care Research
- Department of Health and Social Care
- Guarantors of Brain
- University of Cambridge
- Cambridge University Hospitals
- Evelyn Trust
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre