Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation
Psychological stress diminishes the efferocytotic capacity of PD-L2-positive macrophages, causing an accumulation of dead cells. This, in turn, heightens eosinophil infiltration through Caspase-1-dependent production of CCL24, exacerbating IgE-CAI.
Authors
- Keiji Naruse (ORCID: https://orcid.org/0000-0003-4100-6444)
- Takeshi Y. Hiyama (ORCID: https://orcid.org/0000-0001-8612-8707)
- Hitoshi Urakami
- Soichiro Yoshikawa (ORCID: https://orcid.org/0000-0003-1820-3829)
- Sachiko Miyake (ORCID: https://orcid.org/0000-0001-6349-2936)
- Atsushi Fujimura (ORCID: https://orcid.org/0000-0002-8638-5460)
- Kei Nagao
- Shin Morizane (ORCID: https://orcid.org/0000-0003-1374-065X)
- Yuki Fujita (ORCID: https://orcid.org/0000-0002-7490-258X)
- Shuhei Sano
- Kenji Takamori (ORCID: https://orcid.org/0000-0002-0644-0504)
- Kensuke Miyake (ORCID: https://orcid.org/0000-0003-1149-3755)
- Tsuyoshi Inoue (ORCID: https://orcid.org/0000-0003-2208-7584)
- Mitsutoshi Tominaga
- Hajime Karasuyama (ORCID: https://orcid.org/0000-0003-0689-0836)
- Zheyu Hu
- Ryusuke Umene (ORCID: https://orcid.org/0009-0001-7452-235X)
- A. Komura
- Miho Nakashima
- Emi Nishii
Institutions
- Tokyo Medical and Dental University (JP)
- Okayama University (JP)
- Juntendo University (JP)
- Nagasaki University (JP)
- Tottori University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.jaci.2024.10.038
- Citations
- 11
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.73