TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds

A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1<i>H</i>)-ones, and pyrimidin-4(3<i>H</i>)-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroarenes, followed by hydroxylation. This protocol is easy to use, providing access to (hetero)aryl-substituted <i>N</i>-heterocycles in good yields.