SarZ inhibits the hemolytic activity through regulation of phenol soluble modulins in Staphylococcus epidermidis
Taken together, the results confirmed that SarZ is a pivotal regulator of virulence in <i>S. epidermidis</i> and might respectively regulate the hemolytic activity and biofilm formation mainly by directly controlling the transcription of <i>psm</i> genes, particularly the β-type, and the <i>ica</i> operon.
Authors
- Hui Sun (ORCID: https://orcid.org/0000-0003-4677-7299)
- Tao Zhu (ORCID: https://orcid.org/0000-0001-9747-9836)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9861-5577)
- Han Wang (ORCID: https://orcid.org/0000-0003-2420-3147)
- Xiao Chen (ORCID: https://orcid.org/0000-0003-4517-0508)
- Ren Xiang Tan (ORCID: https://orcid.org/0000-0001-6532-6261)
Institutions
- Wannan Medical College (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fcimb.2024.1476287
- Citations
- 2
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Fudan University
- Ministry of Education, India
- Anhui Provincial Department of Education