Therapeutic Efficacy of Boerhaavia diffusa and Tribulus terrestris on Acute Kidney Disease in Dogs

Background: A total of 24 dogs confirmed with acute kidney disease were randomly divided into four treatment groups each comprising 6 dogs. Additionally, six healthy dogs were selected as the healthy control group. Method: A total of 24 dogs confirmed for acute kidney disease were divided randomly into four treatment groups i.e., G2, G3, G4, and G5 each comprising of 6 dogs. Six healthy dogs were selected as the healthy control group (G1). Dogs of group G2 were treated with Enalapril, G3 were treated with Pulv. Boerhaavia diffusa, G4 were treated with Pulv. Tribulus terrestris and G5 with the combination of Pulv. Boerhaavia diffusa and Pulv. Tribulus terrestris. Supportive treatment was given as per the requirement in all the treatment groups. Result: Haematological parameters showed a significant decrease in Hb, TEC and PCV on day 0 (pre-treatment) in all dogs. Biochemical parameters revealed a significant increase in the values of serum creatinine, BUN, ALP, and AST levels while serum sodium concentration decreased. Proteinuria was observed on urinalysis. However, on day 30 (post-treatment) significant improvement was observed in the values of haemato-biochemical and urinary parameters.