Genetic variants associated with age‐related episodic memory decline implicate distinct memory pathologies
We demonstrated the contribution of the common polygenic risk of Alzheimer's disease to episodic memory decline. We discovered and replicated two risk genes associated with episodic memory decline implicated by rare variants, were discovered and replicated. We demonstrated molecular mechanisms and potential novel memory pathologies underlying interfacial rare coding variants. Molecular dynamics simulations were performed to understand the downstream effects of risk rare coding variants.
Authors
- Erica Weiss
- Nir Barzilai (ORCID: https://orcid.org/0000-0002-7787-6268)
- Valerio Napolioni (ORCID: https://orcid.org/0000-0002-4378-6838)
- Jhih‐Rong Lin (ORCID: https://orcid.org/0000-0001-5050-4352)
- Zhengdong D. Zhang (ORCID: https://orcid.org/0000-0001-9508-1429)
- Amanat Ali
- Sofiya Milman (ORCID: https://orcid.org/0000-0001-9247-0082)
- Tina Gao
Institutions
- Università di Camerino (IT)
- Albert Einstein College of Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14379
- Citations
- 3
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- Foundation for the National Institutes of Health
- Regeneron Pharmaceuticals
- National Institutes of Health