Black Soybean Seed Coat Extract Suppresses Gut Tumorigenesis by Augmenting the Production of Gut Microbiota-Derived Short-Chain Fatty Acids
Diet supplemented with black soybean-derived PACs could prevent CRC development in mice through gut microbiome remodeling. Regions consuming black soybeans have low CRC incidence. Notably, the incidence of CRC, breast cancer, and liver cancer was significantly lower in Tamba than in the rest of Hyogo Prefecture or Japan. Future studies should delineate the mechanisms underlying the CRC-protective effects of PACs. Nevertheless, our results demonstrate the potential of including PACs in dietary recommendations for cancer prevention.
Authors
- Yoko Yamashita (ORCID: https://orcid.org/0000-0001-6288-5746)
- Takeshi Fukumoto (ORCID: https://orcid.org/0000-0003-0364-711X)
- Namiko Hoshi (ORCID: https://orcid.org/0000-0003-2768-3991)
- Ryohei Sasaki (ORCID: https://orcid.org/0000-0002-4994-9386)
- Mohammed Salah (ORCID: https://orcid.org/0000-0003-2814-0809)
- Naritoshi Mukumoto
- Hitoshi Ashida (ORCID: https://orcid.org/0000-0003-3562-5601)
- Shunta Hirano
- Daisuke Miyawaki (ORCID: https://orcid.org/0000-0003-2094-081X)
- Ai Nakaoka
- Yasuyuki Shimizu
- Takeaki Ishihara
Institutions
- Mukogawa Women's University (JP)
- South Valley University (EG)
- Osaka Metropolitan University (JP)
- Kobe University (JP)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-15
- DOI
- https://doi.org/10.3390/cancers16223846
- Citations
- 2
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 0.85