Lewis acid-catalyzed regiodivergent <i>N</i>-alkylation of indazoles with donor–acceptor cyclopropanes
A regiodivergent N -alkylation of indazoles via the nucleophilic ring opening has been described. Under catalysis with Al(OTf) 3 , kinetic controlled N 2 -alkyl indazoles were obtained, while Co(NTf 2 ) 2 facilitated the formation of N 1 -alkyl indazoles.
Authors
- Yungui Peng (ORCID: https://orcid.org/0000-0002-5815-1261)
- Yujiao Xiang
- Xin Zhou (ORCID: https://orcid.org/0000-0002-8687-0191)
- Weiliang Chen (ORCID: https://orcid.org/0000-0002-4891-945X)
- Xiangyang Zhao
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-0300-8206)
Institutions
- Southwest University (CN)
- Zhejiang Medicine (China) (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1039/d4qo01493f
- Citations
- 5
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.25