Association of precuneus Aβ burden with default mode network function
Precuneus (PRC) Aβ burden impacts DMN function in different cognitive stages. High PRC Aβ burden is linked to early neural compensation and subsequent dysfunction. Low PRC Aβ burden correlates with neural changes before significant Aβ accumulation. Changes in DMN function and connectivity provide insights into AD progression. Early detection of regional Aβ burden can help monitor the risk of cognitive decline.
Authors
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-0375-7135)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Liang Cui (ORCID: https://orcid.org/0000-0003-1112-6162)
- Yaoyao Tu (ORCID: https://orcid.org/0009-0000-5218-5770)
- Qihao Guo (ORCID: https://orcid.org/0000-0001-5079-8047)
- Yuehua Li (ORCID: https://orcid.org/0000-0001-8028-248X)
- Min Wang (ORCID: https://orcid.org/0000-0003-1756-1405)
- Yihui Guan (ORCID: https://orcid.org/0000-0002-2946-4293)
Institutions
- Shanghai University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Sixth People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14380
- Citations
- 13
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.46
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China