Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial

rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination. Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP<sub>1,2</sub>) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. After a post-vaccination peak, each vaccination strategy was associated with a decrease of anti-EBOV GP<sub>1,2</sub> antibody concentrations with distinct kinetics, highlighting a less-rapid decline in antibody levels after vaccination by rVSVΔG-ZEBOV-GP. One year after administration of the vaccine, antibody concentrations were higher in children compared to adults for both vaccines, although with different effect sizes: 1.74-fold higher concentrations (95% confidence interval [CI] [1.48; 2.02]) for children 12-17 years old to 3.10-fold higher concentrations (95% CI [2.58; 3.69]) for those 1-4 years old compared to adults for Ad26.ZEBOV, MVA-BN-Filo versus 1.36-fold (95% CI [1.12; 1.61]) to 1.41-fold (95% CI [1.21; 1.62]) higher than these values for adults, with relatively small changes from one age category of children to another, for rVSVΔG-ZEBOV-GP. Antibody concentrations also differed according to geographical location, pre-vaccination antibody concentration, and sex. In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols.<b>Trial registration:</b> ClinicalTrials.gov identifier: NCT02876328.

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Journal
Emerging Microbes & Infections
Published
2024-11-19
DOI
https://doi.org/10.1080/22221751.2024.2432353
Citations
2
Primary Topic
Viral Infections and Outbreaks Research
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article
Field-Weighted Citation Impact
0.78

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article

Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial

Benetta C. Andrews, Natasha Howard, Papa Ndiaga Cissé, Fatoumata Diallo et al.
2 citations
Emerging Microbes & Infections
Viral Infections and Outbreaks Research
0.78
article

Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial

Benetta C. Andrews, Natasha Howard, Papa Ndiaga Cissé, Fatoumata Diallo, Kelly Cahill, Éric D’Ortenzio, David Ishola, Augustin Augier, Bockarie Koroma, Aurélie Wiedemann, Moses Massaquoi, Dickens Kowuor, Alain DuChêne, Nelson Dozier, Bruce Thompson, Aminata Bagayoko, Hilary Whitworth, Rita Lukoo Ndamenyaa, Robert Akpata, Babajide Keshinro, John McCullough, Teedoh Beyslow, Sibiry Samake, Beth Baseler, Richard Kojan, Julia Lysander, Tijili Tyee, Barbara Cagniard, Jens H. Kuhn, Soumaya Mohamed, Amy Falk Russell, A. Tour, David Vallée, Ydrissa Sow, Steven Mazur, Michael J. Stirratt, Maxime Schvartz, Melvin Johnson, Brian Köhn, Courtney Lambeth, Yusupha Njie, Bolarinde Lawal, Melissa E. Hughes, Natasha Dubois Cauwelaert, Cynthia Robinson, Shuǐqìng Yú, Marie Alexandre, Édouard Lhomme, Henry Clifford Lane, Tienhan Sandrine Dabakuyo‐Yonli, Bode Shobayo, Moses Badio, Laura Richert, Robert Phillips, Katherine Cone, Jeroen N. Stoop, Rachael Bonawitz, Blandine Binachon, J.W. Tierney, Micki Nelson, Waly Diouf, Jenny Hendriks, Maarten Leyssen, Elisabeth Higgs, Philip Sahr, Florence Chung, Mary Smolskis, Boris Lacarra, Lamin Molecule Bangura, Tyler M. Brady, Ibrahim Sanogo, Page Crew, Julia García Gozalbes, Laure Masson, Claire Bauduin, Brian Greenwood, Peter Piot, Patricia Boison, Julie Blie, Pauline Michavila, Edouard Lhomme, Andrew Wen-Tseng Lee, Hélène Espérou, Nadeeka Randunu, Solange Lancrey-javal, Irina Maljkovic Berry, Lawrence Fakoli, Bionca Davis, Karen Slater, Guillaume Thaurignac, Harrison Gichini, Samba Diop, Trudi Hilton, Lindsay Marron, Myriam Kanté, Séverine Ciancia, Siew Pin Chai, Pauline Akoo, Delphine Yamadjako, Abdoul Habib Béavogui, Daniel Tindanbil, Ayouba Diarra, Mélanie Prague, Chelsea McLean, Janie Liang, Nathalie Swales, Micheal Piziali, Yíngyún Caì, Judith Katoudi, Sara Albert, Jennifer Cash, Viki Bockstal, Eline Dekeyster, Vinh‐Kim Nguyen, Auguste Gaddah, Macaya Douoguih, Mohamed Samai, Michael Duvenhage, Laurie Connor, Laurie Lambert, Alexandre Quach, Kokulo Franklin, Djénéba Dabitao, Sandrine Couffin-Cardiergues, Jayanthi Wolf, Inmaculada Ortega‐Pérez, Mamoudou Kodio, Laurie Doepel, Jemee Tegli, Mosoka Fallah, Luisa Enria, Boni Maxime Ale, Bonnie Dighero-Kemp, Birgit Grund, Djélikan Siaka Conde, Elena Postnikova, Maima Gray, Jamila Aboulhab, Deborah Watson‐Jones, Barthalomew Wilson, Calvin Proffitt, Abby Balde, Gregory Kocher, Billy Muyisa Sivahera, Jonathan Marchand, Fadima Cheick Haidara, Sani Sayadi, Aboubacar Kaba, Julius Teahton, Renaud Vatrinet, Shelly Simpson, Negin Atri, Nicholas E. 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Bolay, Michael Kamara, Céline Roy, Priscille Rivière, Cécile Etienne, Wissedi Njoh, Denise Shelley, Chan Tang, Karine Fouth Tchos, Stephane Anoma, Shelley Lees, Cécilia Campion, Oumar Guindo, Susan Orsega, Tracey Miller, Céline Colin, Marcel Yaradouno, Allison Eyler, Sushma Patel, Kesha Barrington, Alejandra Miranda, Vemy Fofana, John Fayiah, Cheick Mohamed Keita, Davy Oulaï, Niouma Pascal Millimouno, Barry Djenabou, Catherine Kpayieli-Freeman, Michelle Aguirre-MacKenzie, Quiawiah Yarmie, Serry Alimamy-Bangura, Pierre Andong, David Kollie, Shadrach Langba, Mameni Linga, Marvington Mambiah, Danielle Peart, Elvis Towalid, Jeanne Billioux, Elfrida Cline-Cole, Léa Surugue, Michael Chea, Joséphine Balssa, Kadé Kallon, Yvonne Jato, Christine Lacabaratz, Aissata Abdoulaye Camara, Ken Liu, Saurabh Dixit, Elizabeth Elliott, Eun-Jin Choi, Mahamadou Diakité, Sylvain Landry Faye, Huanying Zhou, Serge Sawadogo, Michael Belson, Christelle Delmas, Samba Diarra, Ahidjo Ayouba, Seykou Keita, Nathan Peiffer-Smadja, Tom Mooney, Yazdan Yazdanpanah, Brian Greenwood, Christine Schwimmer, Rodolphe Thiébaut, Swati Gupta, Jean-François Delfraissy, Amadou Sow, Wouter Willems, Yves Lévy, Emma Hancox, Dally Muamba, Nico Grobler, Guna Subramaniam, Sarah M. Browne, Betsey Herpin, Corine Vincent, Elizabeth Smout, Samuel Bosompem, Mark Kieh, Fatoumata Coulibaly, Ibrah Mahamadou, Charly Matard, Stacey Traina, James D. Neaton, Wade Weaver, Cédrick Wallet, Bailah Leigh, Stacy L. Kopka, Jérôme Pierson, H. Preston Holley, Awa Traoré, Skip Irvine, Madison Joe, Anne-Gaëlle Borg, Aboubacar Keira Camara, Michelle Chouinard, Jean-Christophe Hébert, Moumouni Kinda, Jimmy Whitworth, Ryan Bullis, Julie Gardner, Yves Lévy, Susan Vogel, Patricia Hensley, Matthew Kirchoff, Fatou Secka, Uma Onwuchekwa, Annabelle Lefevre, Noémie Mercier, Sophia Siddiqui, Ali Bauder, Francois Chambelin, Alseny Camara, James Pettitt, Stéphany Pong, Sienneh Tamba, Cecelia Wesseh, Antoine Campagne, Daniela Manno, Sinead Quigley, Alie Wurie, Lucy Chung, Greg Grandits, Yeya Sadio Sarro, Oualy Diawara, Liane Kwast, Emily Snowden, Cynthia Osborne, Deborah Watson-Jones, Claire Levy-Marchal, Seydou Doumbia, Mickael Hneino, Brent Killinger, Katherine McFadyen, Safaa Ben-Farhat, Nicolas Bernaud, Neirade Biai, Alexandre Cantan, Marie Poupelin, Benjamin Hamz, Tracey-Ann Höeltermann, Cece Francis Koli, Jacques Seraphin Koli
article en
2 citations

Abstract

rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination. Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP<sub>1,2</sub>) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. After a post-vaccination peak, each vaccination strategy was associated with a decrease of anti-EBOV GP<sub>1,2</sub> antibody concentrations with distinct kinetics, highlighting a less-rapid decline in antibody levels after vaccination by rVSVΔG-ZEBOV-GP. One year after administration of the vaccine, antibody concentrations were higher in children compared to adults for both vaccines, although with different effect sizes: 1.74-fold higher concentrations (95% confidence interval [CI] [1.48; 2.02]) for children 12-17 years old to 3.10-fold higher concentrations (95% CI [2.58; 3.69]) for those 1-4 years old compared to adults for Ad26.ZEBOV, MVA-BN-Filo versus 1.36-fold (95% CI [1.12; 1.61]) to 1.41-fold (95% CI [1.21; 1.62]) higher than these values for adults, with relatively small changes from one age category of children to another, for rVSVΔG-ZEBOV-GP. Antibody concentrations also differed according to geographical location, pre-vaccination antibody concentration, and sex. In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols.<b>Trial registration:</b> ClinicalTrials.gov identifier: NCT02876328.

Emerging Microbes & InfectionsVol. 14(1)
Université Claude Bernard Lyon 1 (FR), Leidos (United States) (US), University of Maryland, Baltimore (US), Merck & Co., Inc., Rahway, NJ, USA (United States) (US), National Institutes of Health (US), University of Minnesota (US), Institut de Recherche pour le Développement (BJ), Université de Bordeaux (FR), Inserm (FR), University of Sierra Leone (SL), Université Paris-Est Créteil (FR), Université de Montpellier (FR), Université Paris Cité (FR), Ministère de la Santé et de l'Hygiène Publique (ML), Paris-Est Sup (FR), University of Minnesota System (US), Centre Hospitalier Universitaire de Bordeaux (FR), Service de Santé des Armées (FR), Sorbonne Université (FR), Centre Pour le Développement des Vaccins-Mali (ML), London School of Hygiene & Tropical Medicine (GB), Université Sorbonne Paris Nord (FR), Liberian Institute for Biomedical Research (LR), Sorbonne Paris Cité (FR), Alliance for International Medical Action (SN), Assistance Publique – Hôpitaux de Paris (FR), Planned Parenthood Association of Liberia (LR), Bordeaux Population Health (FR), Université des Sciences, des Techniques et des Technologies de Bamako (ML), Agence Nationale de Recherches sur le Sida et les Hépatites Virales (FR), Institut de Recherche Vaccinale (FR), National Center for Emerging and Zoonotic Infectious Diseases (US), Hôpitaux Universitaires Henri-Mondor (FR), Institut Bergonié (FR), National Institute of Allergy and Infectious Diseases (US), Institut National de Santé Publique (CI), Ministère de la Santé (LU), Hôpital Bichat-Claude-Bernard (FR), Institut National de Santé Publique (GN), Janssen (Netherlands) (NL), National Institute of Mental Health (US), Institut de Recherche pour le Développement (FR), Centre d'Investigation Clinique Plurithématique de Bordeaux, Leidos Biomedical Research Inc. (United States), Université de Montréal (CA), Bernhard Nocht Institute for Tropical Medicine (DE), Cheikh Anta Diop University (SN)
London School of Hygiene and Tropical Medicine, Frederick National Laboratory for Cancer Research, European Federation of Pharmaceutical Industries and Associations, European Commission, Institut National de la Santé et de la Recherche Médicale, Ministère de l'Enseignement Supérieur et de la Recherche, Centre National de la Recherche Scientifique, Université de Bordeaux, Innovative Medicines Initiative, Bavarian Nordic, National Institutes of Health, Merck Sharp and Dohme, Horizon 2020, National Institute of Allergy and Infectious Diseases, Janssen Alzheimer Immunotherapy Research And Development, Center for Biomedical Informatics and Information Technology, National Cancer Institute
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