Retrospective Dosimetric Comparison of HDR Interventional Radiotherapy (Brachytherapy) Versus Planning with VMAT and Electron Beam Therapy for Non-Melanoma Skin Cancer Treatment

This study compares dosimetric outcomes of high-dose-rate (HDR) interventional radiotherapy (IRT) using Iridium-192, Volumetric Modulated Arc Therapy (VMAT), and electron beam therapy for non-melanoma skin cancer (NMSC). A retrospective analysis of 25 patients showed that IRT provided a significantly higher mean dose to the clinical target volume (CTV) compared to VMAT and electron beam therapy. IRT and VMAT had comparable V95%CTV coverage, whilst electron therapy was less feasible for large CTVs. IRT delivered higher surface doses while minimizing deep tissue exposure compared to partial arc VMAT. Our findings support IRT for personalized and effective NMSC treatment.

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Publication Details

Journal
Applied Sciences
Published
2024-11-19
DOI
https://doi.org/10.3390/app142210669
Citations
2
Primary Topic
Nonmelanoma Skin Cancer Studies
Type
article
Field-Weighted Citation Impact
0.77
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article

Retrospective Dosimetric Comparison of HDR Interventional Radiotherapy (Brachytherapy) Versus Planning with VMAT and Electron Beam Therapy for Non-Melanoma Skin Cancer Treatment

Bruno Fionda, Valentina Lancellotta, Maria Antonietta Gambacorta, Gabriele Ciasca et al.
2 citations
Applied Sciences
Nonmelanoma Skin Cancer Studies
0.77
article

Retrospective Dosimetric Comparison of HDR Interventional Radiotherapy (Brachytherapy) Versus Planning with VMAT and Electron Beam Therapy for Non-Melanoma Skin Cancer Treatment

Bruno Fionda, Valentina Lancellotta, Maria Antonietta Gambacorta, Gabriele Ciasca, Francesco Pastore, Marco De Spirito, Elisa Placidi, Antonio Napolitano, Martina De Angeli, Luca Tagliaferri, Enrico Rosa
article en
2 citations

Abstract

This study compares dosimetric outcomes of high-dose-rate (HDR) interventional radiotherapy (IRT) using Iridium-192, Volumetric Modulated Arc Therapy (VMAT), and electron beam therapy for non-melanoma skin cancer (NMSC). A retrospective analysis of 25 patients showed that IRT provided a significantly higher mean dose to the clinical target volume (CTV) compared to VMAT and electron beam therapy. IRT and VMAT had comparable V95%CTV coverage, whilst electron therapy was less feasible for large CTVs. IRT delivered higher surface doses while minimizing deep tissue exposure compared to partial arc VMAT. Our findings support IRT for personalized and effective NMSC treatment.

Applied SciencesVol. 14(22)
Università Cattolica del Sacro Cuore (IT), Università degli Studi eCampus (IT), Agostino Gemelli University Polyclinic (IT), Bambino Gesù Children's Hospital (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Good health and well-being
Openalex Percentile: Top 24%
Nonmelanoma Skin Cancer Studies
0.77
DOIOpen Access PDFOpenAlex
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