Conversion to Alzheimer's disease dementia from normal cognition directly or with the intermediate mild cognitive impairment stage
We investigated the disease progression difference between patients who converted to Alzheimer's disease (AD) dementia from normal cognition (NC) directly or through the mild cognitive impairment (MCI) stage. We found that the NC-MCI-AD group showed greater impairment in cognitive and functional scores at AD dementia diagnosis. We discovered that the NC-AD group had rapid functional decline once patients were confirmed with AD onset.
Authors
- Charles Bernick (ORCID: https://orcid.org/0000-0003-4040-3587)
- Xinlin Lu (ORCID: https://orcid.org/0000-0003-2956-921X)
- Guogen Shan (ORCID: https://orcid.org/0000-0001-8690-6599)
- Yichen Tang (ORCID: https://orcid.org/0000-0002-1032-0636)
- Yahui Zhang (ORCID: https://orcid.org/0000-0003-1965-6520)
Institutions
- Cleveland Clinic (US)
- Lou Ruvo Brain Institute (US)
- University of Florida (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14393
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- National Institutes of Health
- National Institute on Aging