Endogenous Glucagon‐Like Peptide‐1 Receptor and Glucose‐Dependent Insulinotropic Polypeptide Receptor Signaling Inhibits Aeroallergen‐Induced Innate Airway Inflammation
Deficiency of both GLP-1R and GIPR signaling together increased TSLP release, ILC2 activation, and early type 2 innate immune responses to aeroallergen exposure. Combined GLP-1R and GIPR signaling should be explored for the treatment of asthma.
Authors
- Christian M. Warren
- Mark Rusznak
- Shinji Toki (ORCID: https://orcid.org/0000-0003-4379-9118)
- Masako Abney
- Dawn C. Newcomb (ORCID: https://orcid.org/0000-0003-2592-9433)
- Katherine N. Cahill (ORCID: https://orcid.org/0000-0002-8549-1835)
- Kevin D. Niswender (ORCID: https://orcid.org/0000-0001-6994-8738)
- R. Stokes Peebles (ORCID: https://orcid.org/0000-0002-1429-7875)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-5552-0132)
- Daniel J. Drucker
Institutions
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Vanderbilt University (US)
- Lunenfeld-Tanenbaum Research Institute (CA)
- VA Tennessee Valley Healthcare System (US)
Publication Details
- Journal
- Allergy
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1111/all.16402
- Citations
- 5
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Allergy and Infectious Diseases