Visual read of [F‐18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Visual assessments of Tau-PET FQT revealed four distinct uptake groups: tau-negative (T-), MTL-only (T+<sub>MTL</sub>), neocortex-only (T+<sub>Neo</sub>), or both (T+<sub>MTL&Neo</sub>). Amyloid positive participants in the T+<sub>MTL</sub> and T+<sub>MTL&Neo</sub> categories showed a retrospectively faster decline in their cognitive trajectories, and a sharper increase in pTau217 levels in plasma, compared to T-. The T+<sub>MTL&Neo</sub> group displayed sharper trajectories compared with the other Tau positive groups in both their cognitive scores and pTau217 plasma levels. Our results suggest that participants with Tau present in both MTL and neocortex represent an intermediate to advanced stage of AD, whereas participants with signals confined to either MTL or neocortex could represent earlier AD stages.
Authors
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Bradley Christian (ORCID: https://orcid.org/0000-0001-5072-3512)
- Mathias Bähr (ORCID: https://orcid.org/0000-0002-9570-1592)
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Laura B. Eisenmenger (ORCID: https://orcid.org/0000-0001-6764-4239)
- Nathaniel A. Chin (ORCID: https://orcid.org/0000-0001-8008-9356)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Ramiro Eduardo Rea Reyes (ORCID: https://orcid.org/0000-0001-9749-282X)
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Lindsay R. Clark (ORCID: https://orcid.org/0000-0003-4837-7627)
- Rebecca E. Langhough
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3298-6324)
- Olivia Mandel
- Madilynn Wintlend
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Geriatric Research Education and Clinical Center (US)
- UK Dementia Research Institute (GB)
- William S. Middleton Memorial Veterans Hospital (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/alz.14406
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- European Commission
- Vetenskapsrådet
- National Institutes of Health
- HORIZON EUROPE Framework Programme