Effect of a Concurrent Training Program with and Without Metformin Treatment on Metabolic Markers and Cardiorespiratory Fitness in Individuals with Insulin Resistance: A Retrospective Analysis
The 12-week inter-day concurrent training program, whether combined with metformin or not, was similarly effective in improving metabolic markers in patients with insulin resistance as metformin treatment alone. Both exercise groups demonstrated a significant reduction in insulin sensitivity and an increase in maximal fat oxidation. Meanwhile, exclusive pharmacological treatment with metformin markedly decreased cardiorespiratory fitness, and consequently, fat oxidation.
Authors
- Alex Ojeda-Aravena (ORCID: https://orcid.org/0000-0002-2406-9622)
- Bibiana Calvo‐Rico
- Marcelo Tuesta (ORCID: https://orcid.org/0000-0002-5711-7520)
- Jairo Azócar-Gallardo (ORCID: https://orcid.org/0000-0002-0552-2487)
- José Manuel García‐García (ORCID: https://orcid.org/0000-0002-1817-1161)
- Tomás Herrera-Valenzuela (ORCID: https://orcid.org/0000-0002-5219-5896)
- Eduardo Báez-San Martín (ORCID: https://orcid.org/0000-0002-3881-1015)
- Luis González-Rojas (ORCID: https://orcid.org/0000-0002-2364-0508)
Institutions
- Universidad de Santiago de Chile (CL)
- Universidad Andrés Bello (CL)
- Pontificia Universidad Católica de Chile (CL)
- Viña del Mar University (CL)
- Universidad de Playa Ancha de Ciencias de la Educación (CL)
- Universidad de Los Lagos (CL)
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Biomolecules
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3390/biom14111470
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.98