Yield of Targeted Polymerase Chain Reaction in Probable Early-Onset Sepsis: A Prospective Cohort Study in Term and Near-Term Neonates With Negative Blood Culture Results
Blood culture-negative "probable" EOS in neonates is accompanied by an 8% rate of PCR positivity, suggesting low-grade bacteriemia after birth with yet unclear clinical consequences. Further research should focus on how PCR can contribute to more targeted antibiotic use of neonates, specifically in those highly suspected of infection but in the absence of a positive blood culture result.
Authors
- Mireille van Westreenen (ORCID: https://orcid.org/0000-0002-7705-7342)
- Corné H. W. Klaassen (ORCID: https://orcid.org/0000-0002-3439-0903)
- Fleur M. Keij (ORCID: https://orcid.org/0000-0002-1469-1952)
- Gerdien A. Tramper‐Stranders (ORCID: https://orcid.org/0000-0002-0228-5375)
- René F. Kornelisse
Institutions
- Erasmus MC (NL)
- Sint Franciscus Gasthuis (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1093/ofid/ofae681
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw