Evaluation of the recently established Dutch nationwide Archipelago of Ovarian Cancer Research biobank
Fundamental and translational research in ovarian cancer aims to enhance understanding of disease mechanisms and improve treatment and survival outcomes. To support this, we established the Dutch multicenter, interdisciplinary Archipelago of Ovarian Cancer Research (AOCR) infrastructure, which includes a nationwide biobank. In this study, we share our experiences in establishing the infrastructure, offer guidance for similar initiatives, and evaluate the AOCR patient cohort. Key challenges included obtaining Data Protection Impact Assessment (DPIA) clearance, drafting the consortium agreement, and securing ethical approval from all hospitals. Over three years, 1093 patients were enrolled across 17 hospitals, resulting in the collection of 1339 tissue samples and 2280 blood samples. Of the 523 patients with currently available clinical and pathological data, 74 % (n = 387) had primary ovarian cancer. Among these patients, 73.4 % was diagnosed with high-grade serous ovarian carcinoma, and 80.9 % presented with advanced-stage disease. Surgery was performed on 93 % of patients with primary ovarian cancer, and chemotherapy was administered to 90.4 % of these patients. In conclusion, the AOCR biobank has established a robust foundation for future fundamental and translational ovarian cancer research. This manuscript provides valuable insights and guidance for developing future research infrastructures and biobanks, and contains detailed information about the AOCR patient cohort to date.
Authors
- Christianne Lok (ORCID: https://orcid.org/0000-0001-8693-7299)
- Michiel Simons (ORCID: https://orcid.org/0000-0003-1039-3488)
- Floris H. Groenendijk (ORCID: https://orcid.org/0000-0001-5057-561X)
- Mariël Brinkhuis (ORCID: https://orcid.org/0000-0002-3456-0503)
- Anna K.L. Reyners (ORCID: https://orcid.org/0000-0003-1678-7816)
- Cornelis G. Gerestein (ORCID: https://orcid.org/0000-0003-0490-2258)
- Refika Yigit (ORCID: https://orcid.org/0000-0001-7379-2203)
- Nils Köster
- Quirinus J.M. Voorham
- Frederike Dijk (ORCID: https://orcid.org/0000-0003-3970-6601)
- Inge Ebisch
- Ingrid A Boere (ORCID: https://orcid.org/0000-0002-4857-6346)
- L Alcala
- Maaike A. van der Aa (ORCID: https://orcid.org/0000-0002-2934-2704)
- Tjalling Bosse (ORCID: https://orcid.org/0000-0002-6881-8437)
- Steven L. Bosch (ORCID: https://orcid.org/0000-0002-7947-8853)
- L. Makkus (ORCID: https://orcid.org/0000-0001-6521-7428)
- Annegien Broeks (ORCID: https://orcid.org/0000-0002-8699-5058)
- Marjolein J. Kagie
- Hein S. Zelisse (ORCID: https://orcid.org/0000-0003-4155-6331)
- Jurgen M.J. Piek (ORCID: https://orcid.org/0000-0002-0487-0631)
- Cor D. de Kroon (ORCID: https://orcid.org/0000-0002-7999-4161)
- Hugo M. Horlings (ORCID: https://orcid.org/0000-0003-4782-8828)
- Ronald P. Zweemer (ORCID: https://orcid.org/0000-0003-1829-7773)
- Loes F. S. Kooreman (ORCID: https://orcid.org/0000-0001-8226-8665)
- G. Bea A. Wisman (ORCID: https://orcid.org/0000-0002-4830-3401)
- Sander de Ridder (ORCID: https://orcid.org/0000-0001-7250-7239)
- Klaas J. Hoogduin
- Huberdina P. M. Smedts (ORCID: https://orcid.org/0000-0002-0971-1859)
- Malou L.H. Snijders (ORCID: https://orcid.org/0000-0001-6295-2291)
- Tijmen Bonestroo
- Riena P. Aliredjo
- Nick van Es (ORCID: https://orcid.org/0000-0001-5256-6346)
- Gatske M. Nieuwenhuyzen-de Boer (ORCID: https://orcid.org/0000-0001-7074-6201)
- Eva‐Maria Roes
- Joost Bart (ORCID: https://orcid.org/0000-0002-0985-071X)
- Constantijne H. Mom (ORCID: https://orcid.org/0000-0003-2838-2031)
- Anne M. van Altena (ORCID: https://orcid.org/0000-0003-2598-087X)
- Margriet Collée (ORCID: https://orcid.org/0000-0002-9272-9346)
- Peggy M L H Vencken
- Hans Marten Hazelbag (ORCID: https://orcid.org/0009-0003-2182-6952)
- Maurice P.H.M. Jansen (ORCID: https://orcid.org/0000-0003-1258-9804)
- Jeroen A.M. Beliën (ORCID: https://orcid.org/0000-0002-7160-5942)
- Mignon D J M van Gent
- Ward Hofhuis (ORCID: https://orcid.org/0000-0002-2757-9230)
- Marlou Heeling
- Marc-Jan Janssen
- Sandrina Lambrechts (ORCID: https://orcid.org/0000-0003-0224-8571)
- Marc J. van de Vijver (ORCID: https://orcid.org/0000-0002-2341-3698)
- Arnold‐Jan Kruse
- Trudy G. N. Jonges (ORCID: https://orcid.org/0009-0006-9499-5310)
- Ineke M de Kievit van der Heijden
- Matthijs Stoter
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Thales (Netherlands) (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Sint Franciscus Gasthuis (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Medisch Centrum Haaglanden (NL)
- Eurofins (Netherlands) (NL)
- Amphia Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Oncode Institute (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- PathoFinder (Netherlands) (NL)
- Dordrecht Hospital (ZA)
- Netherlands Comprehensive Cancer Organisation (NL)
- Isala (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Bravis Ziekenhuis (NL)
- Amsterdam University of Applied Sciences (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Annals of Diagnostic Pathology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.anndiagpath.2024.152411
- Citations
- 3
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Amsterdam University Medical Centers
- KWF Kankerbestrijding