Nitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats
Apigenin promotes vasodilation in resistance arteries through endothelial nitric oxide and calcium-activated potassium channels. These findings suggest that apigenin could have therapeutic potential in cardiovascular disease, warranting further clinical research.
Authors
- Marcia Alessandra Arantes Marques (ORCID: https://orcid.org/0000-0002-3673-0086)
- Gustavo Ratti da Silva (ORCID: https://orcid.org/0000-0001-7224-8898)
- Lislaine Maria Klider (ORCID: https://orcid.org/0000-0002-5547-5615)
- Arquimedes Gasparotto (ORCID: https://orcid.org/0000-0003-3433-5098)
- Jane Manfron Budel (ORCID: https://orcid.org/0000-0003-1873-2253)
- Maria Luiza Fidelis da Silva (ORCID: https://orcid.org/0009-0007-5451-2908)
- Emerson Luiz Botelho Lourenço (ORCID: https://orcid.org/0000-0002-1798-7871)
- Francislaine Aparecida dos Reis Lívero (ORCID: https://orcid.org/0000-0001-6533-0850)
- João Costa
Institutions
- Universidade Federal da Grande Dourados (BR)
- Universidade Paranaense (BR)
- Universidade Federal do Paraná (BR)
- Universidade Estadual de Ponta Grossa (BR)
Publication Details
- Journal
- Molecules
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3390/molecules29225425
- Citations
- 4
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.87