Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus
The 1957 H2N2 influenza pandemic virus [A(H2N2)pdm1957] has disappeared from humans since 1968, while H2N2 avian influenza viruses (AIVs) are still circulating in birds. It is necessary to reveal the recurrence risk and potential cross-species infection of these AIVs from avian to mammals. We find that H2 AIVs circulating in domestic poultry in China have genetic and antigenic differences compared to the A(H2N2)pdm1957. One H2N2 AIV has a dual receptor-binding property similar to that of the A(H2N2)pdm1957. Molecular and structural studies reveal that the N144S, and N144E or R137M substitutions in hemagglutinin (HA) enable H2N2 avian or human viruses to bind or preferentially bind human-type receptor. The H2N2 AIV rapidly adapts to mice (female) and acquires mammalian-adapted mutations that facilitated transmission in guinea pigs and ferrets (female). These findings on the receptor-binding, infectivity, transmission, and mammalian-adaptation characteristics of H2N2 AIVs provide a reference for early-warning and prevention for this subtype.
Authors
- Tianyi Zheng (ORCID: https://orcid.org/0000-0003-4072-7047)
- Ju Sun (ORCID: https://orcid.org/0000-0002-2017-5903)
- Yuhai Bi (ORCID: https://orcid.org/0000-0002-5595-363X)
- Honglei Sun (ORCID: https://orcid.org/0000-0002-8702-4341)
- George F. Gao (ORCID: https://orcid.org/0000-0002-3869-615X)
- Jingru Yang
- Wen‐xia Tian (ORCID: https://orcid.org/0000-0001-6018-5180)
- Wenjun Liu (ORCID: https://orcid.org/0000-0001-9380-2990)
- Yi Shi (ORCID: https://orcid.org/0000-0002-3053-2687)
- Yufeng Xie (ORCID: https://orcid.org/0000-0001-9602-0003)
- Jianxun Qi (ORCID: https://orcid.org/0000-0002-9358-4732)
- Mingjun Jia (ORCID: https://orcid.org/0000-0002-5826-8662)
- Yan Liu (ORCID: https://orcid.org/0000-0002-2566-6867)
- Junmin Li (ORCID: https://orcid.org/0000-0003-0775-0878)
- Peng Yang (ORCID: https://orcid.org/0000-0003-0144-2575)
- Jinhua Liu (ORCID: https://orcid.org/0000-0002-4128-1043)
- Qi Tong (ORCID: https://orcid.org/0000-0001-9341-6352)
- Jing Yang (ORCID: https://orcid.org/0000-0002-2457-3634)
- Guanghua Fu (ORCID: https://orcid.org/0009-0004-9579-9691)
- Yanjun Wang (ORCID: https://orcid.org/0000-0001-6121-8706)
Institutions
- Shanxi Agricultural University (CN)
- Fujian Academy of Agricultural Sciences (CN)
- Institute of Microbiology (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Early Warning (United States) (US)
- University of Chinese Academy of Sciences (CN)
- China Agricultural University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1038/s41467-024-54374-z
- Citations
- 7
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Earmarked Fund for Modern Agro-industry Technology Research System
- Youth Innovation Promotion Association