Iodide Anion Enables a Reductive Cross‐Electrophile Coupling for Preparing Tertiary Amines
The reducing power of iodide anion is an underexplored property that can be used for the cross-electrophile coupling of organic molecules. Herein we harness this trait for the preparation of tertiary amines through the combination of two simple reagents: an electrophilic-carbon precursor and an iminium iodide in a dual role - both as nitrogen-containing building block and as reducing agent. The underlying mechanism of this new C-C bond-formation paradigm is explored through a combination of experiment and quantum chemical calculations.
Authors
- Miran Lemmerer (ORCID: https://orcid.org/0000-0003-4391-055X)
- Boris Maryasin (ORCID: https://orcid.org/0000-0001-7943-7333)
- Daniel Kaiser (ORCID: https://orcid.org/0000-0001-8895-9969)
- David Just (ORCID: https://orcid.org/0000-0002-9606-9365)
- Veronica Tona (ORCID: https://orcid.org/0000-0002-0736-6422)
- Andreas B. zur Bonsen (ORCID: https://orcid.org/0000-0001-9111-3876)
- Giovanni Di Mauro (ORCID: https://orcid.org/0000-0002-6123-4543)
- Nuno Maulide (ORCID: https://orcid.org/0000-0003-3643-0718)
- Miloš Vavrík (ORCID: https://orcid.org/0009-0003-2088-1108)
Institutions
- University of Vienna (AT)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1002/anie.202409688
- Citations
- 3
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Austrian Science Fund
- Universität Wien