Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability
These findings together demonstrate that stabilization of YY1 protein by USP15 deubiquitinating activity contributes to USP15-mediated inhibition of HIV-1 transcription and may help the development of USP15-specific UbV inhibitors as an anti-HIV strategy.
Authors
- Khalid Amine Timani (ORCID: https://orcid.org/0000-0002-4862-9348)
- Johnny J. He (ORCID: https://orcid.org/0000-0002-0837-4889)
- Ying Liu (ORCID: https://orcid.org/0000-0003-0634-8158)
- Sahar Rezaei
Institutions
- Rosalind Franklin University of Medicine and Science (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fcimb.2024.1371655
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- University of North Texas
- Rosalind Franklin University of Medicine and Science
- University of Toronto
- National Institutes of Health
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke