Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes
In summary, hepatic nuclear receptors we examined in the present study (FXR, PXR, LXR, and PPARα) did not significantly alter <i>NAT2</i> expression in cryopreserved human hepatocytes. Additional studies are needed to identify transcriptional regulators of hepatic NAT2 expression.
Authors
- Kennedy M. Walls
- Kyung U. Hong (ORCID: https://orcid.org/0000-0001-6700-9470)
- David W. Hein (ORCID: https://orcid.org/0000-0003-3261-9775)
- Anthony P. Aureliano
Institutions
- University of Louisville (US)
- Western New England University (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fphar.2024.1488367
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Environmental Health Sciences