Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators
In conclusion, our studies suggest that novel combinations of modulators, endowed with higher efficacy leading to increased rescue of G85E-CFTR, are needed to improve the clinical benefit in patients for this variant.
Authors
- Renata Bocciardi (ORCID: https://orcid.org/0000-0001-8415-3802)
- Stefano Costa (ORCID: https://orcid.org/0000-0001-5640-1901)
- Emanuela Pesce (ORCID: https://orcid.org/0000-0002-9070-4479)
- Pietro Ripani
- Federico Cresta (ORCID: https://orcid.org/0000-0002-2483-5374)
- Cristina Fevola (ORCID: https://orcid.org/0000-0002-3642-8928)
- Cristina Pastorino (ORCID: https://orcid.org/0000-0001-8565-4393)
- Tiziano Bandiera (ORCID: https://orcid.org/0000-0002-2496-2701)
- Maria Cristina Lucanto
- Elvira Sondo (ORCID: https://orcid.org/0000-0003-0971-2082)
- Vito Terlizzi (ORCID: https://orcid.org/0000-0003-1106-4424)
- Nicoletta Pedemonte (ORCID: https://orcid.org/0000-0002-5161-1720)
- Federico Zara (ORCID: https://orcid.org/0000-0001-9744-5222)
- Luis J. V. Galietta (ORCID: https://orcid.org/0000-0001-8686-3461)
- Anna Borrelli
- Stefano Pantano
- Mariateresa Lena (ORCID: https://orcid.org/0000-0001-9661-2885)
- Francesca Collini (ORCID: https://orcid.org/0000-0001-9694-9111)
- Valeria Tomati (ORCID: https://orcid.org/0000-0003-3761-1916)
- Valeria Capurro (ORCID: https://orcid.org/0000-0002-9740-1171)
- Carlo Castellani (ORCID: https://orcid.org/0000-0003-1916-0963)
Institutions
- Istituto Giannina Gaslini (IT)
- Italian Institute of Technology (IT)
- Cystic Fibrosis Research Foundation (IT)
- Meyer Children's Hospital (IT)
- Azienda Ospedaliera Universitaria Policlinico "G. Martino" (IT)
- Telethon Institute Of Genetics And Medicine (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fphar.2024.1494327
- Citations
- 3
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Cystic Fibrosis Foundation
- Ministero della Salute
- Fondazione per la Ricerca sulla Fibrosi Cistica