Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study
This study demonstrated that CSF levels of neuroinflammation and glycosylation-related proteins were significantly correlated with prospective progression rates in patients with ALS. These proteins could be useful prognostic biomarkers for ALS.
Authors
- Akiyoshi Kunugi
- Tomonori Kunikata
- Keisuke Hirai (ORCID: https://orcid.org/0000-0003-2665-9834)
- Yuishin Izumi (ORCID: https://orcid.org/0000-0002-3048-9041)
- Yoshihiko Hirozane (ORCID: https://orcid.org/0000-0003-1777-7986)
- Koji Fujita (ORCID: https://orcid.org/0000-0003-4789-1579)
- Shotaro Haji (ORCID: https://orcid.org/0000-0003-4768-0317)
- Genta Narazaki (ORCID: https://orcid.org/0000-0003-3063-2570)
- Kimie Nakamura
- Motohisa Suzuki (ORCID: https://orcid.org/0000-0001-8416-2733)
- Hirofumi Kondo (ORCID: https://orcid.org/0009-0009-0884-1115)
- Bitoku Takahashi
Institutions
- Daiichi-Sankyo (Japan) (JP)
- Takeda (Japan) (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fneur.2024.1418320
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Ministry of Health, Labour and Welfare