Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers
Overall, our results not only clarified the active substances and molecular mechanism for enhancing our understanding about the traditional efficacy, but also pay attention to the clinical safety issues of raw and prepared rhubarbs.
Authors
- Zhenhua Wu (ORCID: https://orcid.org/0000-0002-5527-0310)
- Mengqi Jia (ORCID: https://orcid.org/0000-0002-9792-9937)
- Guorong Fan (ORCID: https://orcid.org/0000-0002-4417-7225)
- Wenqing Shi
- Chenxi Wang (ORCID: https://orcid.org/0009-0003-8705-8546)
- Jingjing Jiang (ORCID: https://orcid.org/0000-0002-9207-0190)
- Shiyu Feng (ORCID: https://orcid.org/0009-0001-3060-541X)
- Xin Zhao (ORCID: https://orcid.org/0009-0000-7261-4480)
- Yuefen Lou (ORCID: https://orcid.org/0009-0005-9622-6059)
Institutions
- Tongji University (CN)
- Shanghai University of Finance and Economics (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fphar.2024.1481091
- Citations
- 2
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Shanghai Hospital Development Center