Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection
Within the first week after testing PCR+, children showed a stronger inflammatory innate immune profile and experienced less severe symptoms compared to adults. Our data implies correlations between the secretion of cytokines/chemokines, proportion of non-classical monocytes, and symptoms severity. These findings enhance our understanding of the distinct pediatric and adult innate immune profile after SARS-CoV-2 infection and contributes to the knowledge necessary to improve future prevention strategies.
Authors
- Ronald Jacobi
- Cécile A. C. M. van (ORCID: https://orcid.org/0000-0003-1995-8641)
- Debbie van Baarle (ORCID: https://orcid.org/0000-0001-5463-818X)
- Daphne F. M. Reukers (ORCID: https://orcid.org/0000-0002-3324-6993)
- Nynke Y. Rots (ORCID: https://orcid.org/0000-0002-7170-7826)
- Elena Pinelli (ORCID: https://orcid.org/0000-0002-1281-1308)
- Adam Meijer (ORCID: https://orcid.org/0000-0001-8074-7582)
- Jelle de Wit (ORCID: https://orcid.org/0000-0003-2444-6050)
- Alberto Miranda Bedate (ORCID: https://orcid.org/0000-0003-2623-2857)
- Nening M. Nanlohy (ORCID: https://orcid.org/0000-0003-4597-1516)
- Josine van Beek (ORCID: https://orcid.org/0000-0002-7735-9359)
- Martijn D. B. van de Garde (ORCID: https://orcid.org/0000-0003-0509-7713)
Institutions
- University Medical Center Groningen (NL)
- Utrecht University (NL)
- National Institute for Public Health and the Environment (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1359993
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Ministerie van Volksgezondheid, Welzijn en Sport