Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth
This study classified pregnant women into three immune subtypes, with the excessive inflammatory response subtype showing a higher predisposition to preterm birth. Mid-pregnancy immune status emerged as a key indicator of preterm birth risk, associated with the vaginal microbiome composition. Microorganisms affected the occurrence of preterm birth by modulating immune factor levels, with time-specific mediation roles observed. <i>Lactobacillus crispatus</i> demonstrated potential in protecting against preterm birth by modulating vaginal immune status.
Authors
- Tiantian Wei (ORCID: https://orcid.org/0000-0001-8964-8839)
- Guoping Zhao (ORCID: https://orcid.org/0000-0002-7621-6620)
- Sijie Yang (ORCID: https://orcid.org/0000-0003-2141-853X)
- Changying Zhao (ORCID: https://orcid.org/0000-0003-0023-0378)
- Yijia Liang (ORCID: https://orcid.org/0000-0003-4429-8542)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4284-2604)
- Yan Wen (ORCID: https://orcid.org/0000-0002-4576-7470)
- Tianqi Hu
- Dashuang Sheng
- Junhui Dai
- Q. Wang (ORCID: https://orcid.org/0009-0000-2297-4058)
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Reproductive Medicine
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1481611
- Citations
- 7
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Shandong University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province