Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach
CycleGAN generated synthetic SPECT images visually indistinguishable from real ones and retained disease-specific information, demonstrating the feasibility of translating [<sup>11</sup>C]CFT PET to [<sup>123</sup>I]FP-CIT SPECT. This cross-modality synthesis could enhance further AI classification accuracy, supporting the diagnosis of PD and APS.
Authors
- Qian Xu (ORCID: https://orcid.org/0000-0002-5223-9967)
- Leonor Lopes (ORCID: https://orcid.org/0000-0002-9536-6691)
- Bruce Spottiswoode (ORCID: https://orcid.org/0000-0002-8807-923X)
- Rachid Fahmi (ORCID: https://orcid.org/0000-0001-8277-6125)
- Chuantao Zuo (ORCID: https://orcid.org/0000-0002-8856-7217)
- Axel Rominger (ORCID: https://orcid.org/0000-0002-1954-736X)
- Korbinian Krieger (ORCID: https://orcid.org/0000-0002-5649-0710)
- Ahmed A. Soliman (ORCID: https://orcid.org/0000-0001-5630-0203)
- Ralph Buchert (ORCID: https://orcid.org/0000-0002-0945-0724)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-6522-4895)
- Fangyang Jiao (ORCID: https://orcid.org/0000-0002-2246-0951)
- Jingjie Ge (ORCID: https://orcid.org/0000-0001-6413-5914)
- Ping Wu (ORCID: https://orcid.org/0000-0002-2758-1218)
- Kuangyu Shi (ORCID: https://orcid.org/0000-0002-8714-3084)
- Thomas Pyka (ORCID: https://orcid.org/0000-0002-2686-2851)
- Claudio L. Bassetti (ORCID: https://orcid.org/0000-0002-4535-0245)
- Yihui Guan (ORCID: https://orcid.org/0000-0002-2946-4293)
- Jimin Hong (ORCID: https://orcid.org/0000-0002-4499-2094)
- Song Xue
Institutions
- University of Bern (CH)
- Universität Hamburg (DE)
- Fudan University (CN)
- University Hospital of Bern (CH)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Munich Cluster for Systems Neurology (DE)
- Huashan Hospital (CN)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1007/s00259-024-06961-x
- Citations
- 13
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.80
Funders
- National Science Foundation
- Michael J. Fox Foundation for Parkinson's Research
- University of Bern
- Jacques und Gloria Gossweiler-Stiftung
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Parkinson Schweiz