Reorganized brain functional network topology in stable and progressive mild cognitive impairment
Our study revealed significant differences in network topological properties among sMCI, pMCI and HC patients, which were significantly correlated with cognitive function. Most notably, the cerebellar module played a crucial role in the overall network interactions. In conclusion, these findings could aid in the development of imaging markers used to expedite diagnosis and intervention prior to Alzheimer's disease onset.
Authors
- Xuan Cao (ORCID: https://orcid.org/0009-0005-5728-6075)
- Xulian Zhang
- Wenzhang Qi
- Xuhong Liang (ORCID: https://orcid.org/0000-0002-2675-5837)
- Yiming Ruan
- Qingling Huang (ORCID: https://orcid.org/0000-0002-0117-2467)
- Chen Xue (ORCID: https://orcid.org/0000-0002-9753-0782)
- Darui Zheng
- Qianqian Yuan (ORCID: https://orcid.org/0000-0002-0749-0749)
Institutions
- Nanjing Brain Hospital (CN)
- University of Cincinnati (US)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fnagi.2024.1467054
- Citations
- 6
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research