COVID-19 vaccination survey and anti-SARS-CoV-2 IgG responses in a human cohort from Schistosoma mansoni-endemic villages in Mayuge District, Uganda: a cross-sectional study
Although the acceptance rate of COVID-19 vaccination was high, the majority of participants received only a single vaccine dose and the overall anti-S1 IgG titres in confirmed vaccinees were low. Moderate-to-heavy schistosome infections blunted the antibody responses following vaccination with a single dose of BNT162b2. These observations confirm the necessity for a second COVID-19 vaccine dose for two-dose primary immunization series and call for implementation research that may inform the development of a 'treat and vaccinate' policy during vaccination roll-out in regions with heavy worm burdens.
Authors
- Pengfei Cai (ORCID: https://orcid.org/0000-0003-4975-4615)
- Malcolm K. Jones (ORCID: https://orcid.org/0000-0002-0035-6141)
- Donald P. McManus (ORCID: https://orcid.org/0000-0001-6443-1449)
- Thomas G. Egwang (ORCID: https://orcid.org/0000-0001-8191-0898)
- Moses Adriko (ORCID: https://orcid.org/0000-0001-9748-1207)
- Rowel Candia (ORCID: https://orcid.org/0000-0001-8634-5285)
- Yi Mu
- Mimi Niu
Institutions
- The University of Queensland (AU)
- Hainan University (CN)
- QIMR Berghofer Medical Research Institute (AU)
- Ministry of Health (UG)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fpubh.2024.1437063
- Citations
- 1
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- QIMR Berghofer Medical Research Institute
- Chinese Academy of Medical Sciences
- Medical Research Council
- National Health and Medical Research Council