MALAT1 promotes colonic epithelial cell apoptosis and pyroptosis by sponging miR-22-3p to enhance NLRP3 expression
These findings suggest that MALAT1 represents a promising therapeutic target for the treatment of UC by modulating the miR-22-3p/NLRP3 pathway, potentially leading to novel strategies for reducing inflammation and cell death in the colon.
Authors
- Juan Hu (ORCID: https://orcid.org/0000-0003-0669-3146)
- Rong Yan (ORCID: https://orcid.org/0000-0002-8648-0636)
- Xinghua Liang
Institutions
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-11-18
- DOI
- https://doi.org/10.7717/peerj.18449
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.40