Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis
This study innovatively highlights the dual mechanism of ginsenoside RK3 in glioblastoma treatment: it impedes tumor progression by modulating the PPARG/CCL2 pathway and enhances the efficacy of temozolomide. Our research underscores the promising role of herbal medicine in the management of glioblastoma, paving the way for novel therapeutic strategies that integrate traditional approaches with conventional treatments.
Authors
- Bohao Zheng (ORCID: https://orcid.org/0000-0003-0934-8209)
- Jinpeng Hu
- Ying‐Hao Han (ORCID: https://orcid.org/0000-0003-1917-8610)
- Gang Luo (ORCID: https://orcid.org/0000-0001-7899-4154)
- Haiying Zhang (ORCID: https://orcid.org/0000-0002-7158-2373)
- Xiang Zhao (ORCID: https://orcid.org/0000-0003-3032-7736)
- Deqiang Dou
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1016/j.phymed.2024.156271
- Citations
- 11
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.14