Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer
Our integrated single-cell analysis provides a comprehensive understanding of the tumor heterogeneity in tamoxifen resistance. We envision this integrated single-cell epigenomic and transcriptomic measure will become a powerful approach to unravel how epigenetic factors and the tumor microenvironment govern the development of tumor heterogeneity and to uncover potential therapeutic targets that circumvent heterogeneity-related failures.
Authors
- Sailaja Kamaraju (ORCID: https://orcid.org/0000-0003-3031-9269)
- Bakhtiyor Nosirov (ORCID: https://orcid.org/0000-0002-4644-2758)
- Lavanya Choppavarapu
- Qianben Wang (ORCID: https://orcid.org/0000-0003-2636-7145)
- Tianxiang Liu (ORCID: https://orcid.org/0000-0001-5344-1203)
- Victor X. Jin (ORCID: https://orcid.org/0000-0002-8765-3471)
- Xue‐Zhong Yu (ORCID: https://orcid.org/0000-0002-1751-2884)
- Kun Fang (ORCID: https://orcid.org/0000-0002-2569-8543)
- Gustavo Leone (ORCID: https://orcid.org/0000-0002-7617-7449)
- Aigbe G. Ohihoin
Institutions
- Duke University (US)
- Medical College of Wisconsin (US)
- Luxembourg Institute of Health (LU)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1186/s13073-024-01407-3
- Citations
- 22
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- National Institutes of Health