Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components. Here we conducted a multi-cohort, multi-omic analysis of US and UK populations with detailed dietary information from a total of 22,867 participants, which we then integrated with public data from 211 cohorts (N = 54,198). The link between coffee consumption and microbiome was highly reproducible across different populations (area under the curve of 0.89), largely driven by the presence and abundance of the species Lawsonibacter asaccharolyticus. Using in vitro experiments, we show that coffee can stimulate growth of L. asaccharolyticus. Plasma metabolomics on 438 samples identified several metabolites enriched among coffee consumers, with quinic acid and its potential derivatives associated with coffee and L. asaccharolyticus. This study reveals a metabolic link between a specific gut microorganism and a specific food item, providing a framework for the understanding of microbial dietary responses at the biochemical level.
Authors
- Curtis Huttenhower (ORCID: https://orcid.org/0000-0002-1110-0096)
- Sabrina Tamburini (ORCID: https://orcid.org/0000-0002-2485-7418)
- Kelsey N. Thompson (ORCID: https://orcid.org/0000-0002-9437-9722)
- Paolo Manghi (ORCID: https://orcid.org/0000-0003-0846-6529)
- Mingyang Song (ORCID: https://orcid.org/0000-0002-1324-0316)
- Francesco Asnicar (ORCID: https://orcid.org/0000-0003-3732-1468)
- Davide Golzato (ORCID: https://orcid.org/0000-0002-2890-1527)
- Kate Bermingham (ORCID: https://orcid.org/0000-0002-2530-1614)
- Francesca Giordano (ORCID: https://orcid.org/0000-0003-0144-2081)
- Dong Hang (ORCID: https://orcid.org/0000-0001-6944-0459)
- Jonathan Wolf (ORCID: https://orcid.org/0000-0002-0530-2257)
- Till Strowig (ORCID: https://orcid.org/0000-0003-0185-1459)
- Eric B. Rimm (ORCID: https://orcid.org/0000-0002-1402-7250)
- Sarah Berry (ORCID: https://orcid.org/0000-0002-5819-5109)
- Qi Sun (ORCID: https://orcid.org/0000-0002-8480-1563)
- Manimozhiyan Arumugam (ORCID: https://orcid.org/0000-0002-0886-9101)
- Liviana Ricci (ORCID: https://orcid.org/0000-0001-9450-9235)
- Eric A. Franzosa (ORCID: https://orcid.org/0000-0002-8798-7068)
- Nicola Segata (ORCID: https://orcid.org/0000-0002-1583-5794)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Marta Selma‐Royo (ORCID: https://orcid.org/0000-0002-4258-947X)
- Mireia Valles‐Colomer (ORCID: https://orcid.org/0000-0002-1988-6054)
- George Hadjigeorgiou (ORCID: https://orcid.org/0000-0001-7647-8471)
- Richard Davies (ORCID: https://orcid.org/0000-0003-2050-3994)
- Amir Nabinejad (ORCID: https://orcid.org/0000-0003-3276-1368)
- Wendy S. Garrett (ORCID: https://orcid.org/0000-0002-5092-0150)
- Kai Wang (ORCID: https://orcid.org/0000-0002-5614-5618)
- Wenjie Ma (ORCID: https://orcid.org/0000-0001-9894-7072)
- Tim D. Spector
- Amrisha Bhosle
- Roberta Marconi
Institutions
- Fondazione Edmund Mach (IT)
- Broad Institute (US)
- University of Copenhagen (DK)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Ca' Foscari University of Venice (IT)
- Universitat Pompeu Fabra (ES)
- King's College London (GB)
- University of Trento (IT)
- Novo Nordisk Foundation (DK)
- Massachusetts General Hospital (US)
- ZOE (United Kingdom) (GB)
- Helmholtz Centre for Infection Research (DE)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Nature Microbiology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1038/s41564-024-01858-9
- Citations
- 60
- Primary Topic
- Coffee research and impacts
- Type
- article
- Field-Weighted Citation Impact
- 26.87
Funders
- National Institutes of Health