Synthesis, and antitumoral and antiviral evaluation of polyacetylene glycoside derivatives
A series of novel derivatives of Poliacetylene Glycosides (PAGs) were synthesized, and their antiproliferative and antiviral properties were evaluated. Starting from D-(+)-glucose pentaacetate as a precursor, a commercially available and low-cost starting material, three different strategies were attempted to synthesize the new PAGs, and the desired compounds were obtained in high overall yields after only three steps. The synthesized PAGs exhibited antitumoral activity in concentrations ranging from 68-878 μM and antiviral activities in concentrations ranging from 71-794 μM. Some preliminary structure-activity relationships are also discussed.
Authors
- Paulo H. Menezes (ORCID: https://orcid.org/0000-0002-0327-6032)
- Kléber Juvenal Silva Farias (ORCID: https://orcid.org/0000-0003-3927-444X)
- Cláudia L. A. Almeida (ORCID: https://orcid.org/0000-0003-2272-5996)
- Renato Ferreira de Almeida Júnior (ORCID: https://orcid.org/0000-0001-6181-7864)
- Jonh Anderson Macêdo Santos (ORCID: https://orcid.org/0000-0002-6591-5194)
- Rodrigo Ribeiro Alves Caiana (ORCID: https://orcid.org/0000-0002-7935-6143)
- Daniel Carvalho Pimenta (ORCID: https://orcid.org/0000-0003-2406-0860)
- Juliano Carlo Rufino Freitas (ORCID: https://orcid.org/0000-0003-4617-4084)
- Paula Renata Lima Machado (ORCID: https://orcid.org/0000-0002-3085-9778)
Institutions
- Universidade Federal de Pernambuco (BR)
- Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco (BR)
- Instituto Butantan (BR)
- Universidade Federal do Rio Grande do Norte (BR)
- Universidade Federal de Campina Grande (BR)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1039/d4ob01595a
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Estado da Paraíba
- Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco