Endometriosis: A Century of Unresolved Pathogenesis – It’s Time for Decisive Action

Endometriosis affects around 10% of reproductive-age women, causing severe pain, infertility, and various other symptoms. Traditional treatments, like hormonal therapies and surgeries, often provide temporary relief with significant side effects, The disease’s heterogeneity and varied responses to treatment necessitate a personalized approach. The leading hypothesis for endometriosis onset and recurrence is retrograde menstruation, influenced by factors like uterine position, tubal filtering function by its length and opening sizes, and specific uterine contractility profiles.