Maternal high fat diet exposure modifies amniotic fluid metabolites and expands group 3 innate lymphoid cells dependent on the maternal microbiome and MyD88-signaling
Our findings indicate that mHFD interacts with the maternal microbiome to modify AF metabolites and signal via MyD88 to expand IL17<sup>+ve</sup> ILC3 in murine neonatal offspring.
Authors
- Julie Mirpuri (ORCID: https://orcid.org/0000-0003-4255-3474)
- Mala Mahendroo (ORCID: https://orcid.org/0000-0002-8958-6727)
- Sana Jaleel
- Suzette N. Palmer (ORCID: https://orcid.org/0000-0001-8376-3633)
- Xiaowei Zhan (ORCID: https://orcid.org/0000-0002-6249-7193)
- Dongmei Lu (ORCID: https://orcid.org/0000-0003-2074-0682)
- Xinying Niu
Institutions
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1439804
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases