Restoring brain connectivity by phrenic nerve stimulation in sedated and mechanically ventilated patients
Adding phrenic stimulation on top of invasive mechanical ventilation in deeply sedated, critically ill, moderate acute respiratory distress syndrome patients increases cortical activity, connectivity, and synchronization. The observed changes resemble those during diaphragmatic breathing in awake humans. These results suggest that phrenic nerve stimulation has the potential to restore the brain-diaphragm-lung crosstalk when it has been shut down or impaired by mechanical ventilation and sedation. Further research should evaluate the clinical significance of these results.
Authors
- Steven Reynolds (ORCID: https://orcid.org/0000-0002-2624-640X)
- Mélodie Parfait
- Martin Dres (ORCID: https://orcid.org/0000-0001-9191-6089)
- Jose L. Herrero (ORCID: https://orcid.org/0000-0001-5969-9678)
- Thiago Bassi (ORCID: https://orcid.org/0000-0001-5570-5057)
- Maxens Decavèle (ORCID: https://orcid.org/0000-0003-3552-5053)
- Brett C. Hannigan (ORCID: https://orcid.org/0000-0001-5778-1686)
- Julien Mayaux (ORCID: https://orcid.org/0000-0003-2799-5418)
- Alexandre Demoule
- Thomas Similowski
- Elizabeth Rohrs E
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- Hofstra University (US)
- Inserm (FR)
- University of Toronto (CA)
- ETH Zurich (CH)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Lungpacer Medical (Canada) (CA)
- Assistance Publique – Hôpitaux de Paris (FR)
- Neurophysiologie respiratoire expérimentale et clinique
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1038/s43856-024-00662-0
- Citations
- 6
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.53