Single-cell RNA-seq analysis of cancer-endothelial cell interactions in primary tumor and peritoneal metastasis from a single patient with colorectal cancer
Although limited by its N-of-1 design and requiring further validation, our study provides preliminary observations suggesting that alterations in cancer-endothelial cell interactions could reduce dependence on VEGF signaling and influence immune cell infiltration in CRC peritoneal metastasis.
Authors
- Takashi Akiyoshi (ORCID: https://orcid.org/0000-0002-2321-1412)
- Koji Okabayashi (ORCID: https://orcid.org/0000-0001-8554-1137)
- Reo Maruyama (ORCID: https://orcid.org/0000-0001-7166-5964)
- Yuri Sakimoto
- Shimpei Matsui (ORCID: https://orcid.org/0000-0001-7509-9365)
- Toshiki Mukai (ORCID: https://orcid.org/0000-0002-3553-3590)
- Tomohiro Yamaguchi (ORCID: https://orcid.org/0000-0002-5023-0985)
- Kohei Kumegawa (ORCID: https://orcid.org/0000-0003-3732-2874)
- Seiichi Mori (ORCID: https://orcid.org/0000-0001-8569-4504)
- Yuko Kitagawa (ORCID: https://orcid.org/0000-0002-0271-5670)
Institutions
- Keio University (JP)
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- BJC Reports
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1038/s44276-024-00112-3
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- JST-Mirai Program